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Applications are invited for an enthusiastic Research Assistant / Associate to be a core member of the lab of Dr. Heather Machado in the Department of Pathology, University of Cambridge. The Machado Lab is interested in how tumour and immune cells co-evolve and contribute to cancer progression.
We use methods from evolutionary genetics and multi-omic datasets to study questions such as the timing of the immune response to cancer, the role of inflammation on remodeling the immune response to cancer, and the somatic evolution of the immune response to immunotherapy.
We are searching for a researcher to spearhead laboratory protocol establishment and lead the lab's data generation efforts. Primary responsibilities include tissue processing, flow cytometry, sequencing library preparation and protocol optimization. Applicants should have superb organizational skills and the ability to work independently.
Appointment at Research Associate level is dependent on having a PhD; those without a PhD will be appointed at Research Assistant level. Those who have submitted but not yet received their PhD will be appointed at Research Assistant level, which will be amended to Research Associate once the PhD has been awarded.
Required knowledge, skills and experience
- General molecular biology skills (e.g. PCR, DNA/RNA extraction)
- Flow cytometry (or eagerness to learn)
- Protocol troubleshooting
- Excellent organizational skills, including the detailing of experiments and results
- Excellent oral and written communication skills
- The ability to organise time and work independently
- Enthusiasm to interact with colleagues in a multi-disciplinary and collaborative environment
- At least 2 years of relevant laboratory experience
Desired knowledge, skills and experience
- Tissue dissociation (e.g. tumour)
- Flow cytometry of immune cell populations
- Isolation of peripheral blood mononuclear cells
- Sequencing library construction
- Familiarity with programming in R
Fixed-term: The funds for this post are available for 3 years in the first instance. Start date: September 2024 - February 2025.
Once an offer of employment has been accepted, the successful candidate will be required to undergo a health assessment.
To apply
Applications are welcome from internal candidates who would like to apply for the role on the basis of a secondment from their current role in the University.
Click the 'Apply' button below to register an account with our recruitment system (if you have not already) and apply online. Please quote reference PK42935 on your application and in any correspondence about this vacancy.
The University actively supports equality, diversity and inclusion and encourages applications from all sections of society. The University has a responsibility to ensure that all employees are eligible to live and work in the UK.
