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We are looking for a motivated and dynamic research assistant to join Dr Dan Ma’s lab at Aston Medical School on a two-year Academy of Medical Sciences-funded project focused on neurodegeneration and stem cell biology. The study investigates how APOE4 expression in endothelial cells affects oligodendrocyte progenitor cells (OPCs), using iPSC-derived 3D co-culture models.
This work aims to uncover cellular mechanisms of neurovascular dysfunction in Alzheimer’s disease and identify potential therapeutic targets. The successful candidate will be part of a collaborative team researching myelin protection in neurological disorders, building on recent publications by the group (Ma et al., Glia, 2024; Xu et al., Journal of Neurochemistry, 2025).
The role involves the culture and differentiation of iPSC lines into endothelial cells and OPCs, as well as conducting co-culture experiments to assess APOE4-related cellular interactions.
It requires the use of molecular and cellular biology techniques, including immunocytochemistry, Western blotting, and qPCR, alongside the application of microscopic imaging techniques. Responsibilities also include data collection, analysis, and presentation, as well as contributing to the day-to-day running of the lab.
What we're looking for
Candidates should hold a good BSc or MSc in Neuroscience, Cell Biology, Biomedical Science, Biochemistry, or a related discipline. Practical experience with mammalian cell culture is essential, ideally involving endothelial cells, OPCs, iPSCs, or neural cell models.
Enthusiasm for neuroscience and neurodegenerative disease research is important, along with strong organizational, communication, and teamwork skills. The ability to work both independently and collaboratively within a team is also essential.
The successful candidate will receive training in advanced iPSC technologies, neurodegeneration models, and interdisciplinary collaboration. This is an exciting opportunity to contribute to a growing research programme with the potential to lead to PhD study or further career development in biomedical research.
The salary being offered for this role is below the minimum threshold for required to sponsor new applicants to the Skilled Worker route. However, Aston University may be able to sponsor the successful candidate if they:
- Are under 26 years old
- Hold a PhD that is relevant to the role
- Have held a Student or Graduate visa in the last 2 years
- Are already in the UK with a Tier 2 or Skilled Worker visa issued before April 4th 2024
What we offer
- Aston University is a vibrant campus located within Birmingham city centre, which has excellent transport links via bus or train.
- Excellent training and development opportunities.
- A generous annual leave scheme with 30 days bookable leave and a further 13 days of bank holiday and University closure days.
- Everyday discounts to a number of activities and retailers.
- Great family-friendly policies.
- On-site gym and pool with discounted staff membership available.
- Further information on our Benefits and Rewards can be found here.
Aston University is an equal opportunities employer and welcomes applications from all sections of the community. It promotes equality and diversity in all aspects of its work. We strive to have robust inclusivity strategies in place, including race and sexual orientation, to encourage colleagues to have the confidence and freedom to be themselves in the workplace.
We recognise the value of flexible working. Please contact the recruiting manager to discuss what flexible working options are available for particular roles.
